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B-lymphocytes learn to recognise the enemy that they then have to eliminate through their ability to produce antibodies. If the meeting goes wrong, the “aggressivity” of the B-lymphocytes may be directed towards the wrong enemy or be insufficiently effective. It is therefore essential so that the immune system can eliminate bacteria, parasites, fungi, viruses or even tumour cells. After the approach phase, the B-lymphocyte sticks to the antigen presenting cell to form an immunological synapse.

This is where the exchanges required for activation and learning by the B-lymphocytes take place. The formation of this place of exchange depends on the plasticity of the B-lymphocytes, especially their ability to adapt to the polarity of the meeting. To do so, the cytoskeleton, made of microtubules that are mainly used for intracellular transport and an actin network that controls their shape and movement, must reorganise to meet the new constraints and ensure transport of the ingredients required for the B-lymphocytes’ response.

We have shown that, before the meeting when the lymphocytes are resting, the centrosome is closely linked to the cell nucleus. When it comes into contact with the antigen presenting cell, the lymphocyte is activated. The centrosome detaches from the nucleus and relocates near the immunological synapse. It initiates the polymerisation of the filaments forming the actin network.

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